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    Paolo Vincenzo PEDONE


    Corso di laurea magistrale in MOLECULAR BIOTECHNOLOGY

    SSD: BIO/10

    CFU: 6,00


    Periodo di Erogazione: Primo Semestre


    Lingua di insegnamento





    Teaching language



    Cells in culture and techniques for their study; Cell cycle and control of cell growth in
    eukaryotes; Development of multicellular organisms: integrating cells into tissues; Signal
    Transduction pathways; Cancer.

    Textbook and course materials

    - Molecular Biology of the Cell, sixth edition, (2014), Bruce Alberts, Alexander D. Johnson, Julian
    Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter . W.W. Norton & Company
    - Molecular Cell Biology, Eighth Edition (2016), Harvey Lodish, Arnold Berk, Chris A. Kaiser, Monty
    Krieger, Anthony Bretscher, Hidde Ploegh, Angelika Amon, Kelsey C. Martin. Macmillan Learning.
    - Essential Cell Biology, Fourth edition, Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D.
    Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter. W.W. Norton & Company

    Course objectives

    The course is rooted in an understanding of the molecules within cells and of the interactions
    between cells that allow development of multicellular organisms. Key concepts in cellular
    biochemistry and their experimental underpinnings will be presented. Medically relevant
    examples will be described where appropriate to help illustrate the connections between
    cellular biochemistry and health and human disease. A hallmark of the course is the use of
    experiments to engage students in the history of cell biology and the research that has
    contributed to the field.


    Knowledge and skills in Chemistry and Biology acquired during the Bachelor courses.

    Teaching methods

    Oral lessons and critical reading of original scientific papers

    Evaluation methods

    For the students who attend the course the exam consists of passing an oral exam with a grade of at least 18/30,
    The oral exam is aimed at evaluating the knowledge of the different topics, the reasoning and connection skills between the various topics of the course.

    Other information

    The student can use the supporting teaching material made available on the University website.

    The teacher is available for receiving students on the days indicated on the teaching form and on request sent by e-mail.

    Course Syllabus

    Part I: Cells, the Fundamental Units of Life
    - Course Introduction
    - Chemical Components of Cells, Cells, and Model Organisms
    - Ways of working with cells: Culturing cells, Cell culture Media, Reagents, Cell lines, Cell
    cultures, Primary Cell cultures; Visualizing cells and their components; Identifying and Analysing
    molecules inside the cells and Studying their Interactions.
    - Model Organisms and Trangenesis
    Part II: The Cell-Division Cycle and Cell growth
    - The Eukaryotic Cell Cycle and its regulation
    Part III: Integrating Cells Into Tissues
    - Stem Cells and Pluripotency, Cell Asymmetry.
    - Transcriptional Control of Gene Expression during Development of multicellular organisms; Cell
    Differentiation: Myogenesis, the muscle formation during embryonic development; The
    Formation of the Primary Body Axis, the anterior–posterior axis, during embryonic development
    - Cell Signaling: Signal Transduction and G Protein–Coupled Receptors, human G protein-coupled
    receptors of pharmaceutical importance; Signal Transduction and Receptor Tyrosine Kinase
    (RTK); Signaling Pathways that control Gene Expression; Signaling by Sensory Receptors.
    - Cell Death
    Part IV. Cancer
    - The characteristics of cancer cells and how they differ from normal cells

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