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    Margherita SACCO

    Insegnamento di MOLECULAR MICROBIOLOGY

    Corso di laurea magistrale in MOLECULAR BIOTECHNOLOGY

    SSD: BIO/19

    CFU: 6,00

    ORE PER UNITÀ DIDATTICA: 48,00

    Periodo di Erogazione: Primo Semestre

    Italiano

    Lingua di insegnamento

    Inglese

    English

    Teaching language

    English

    Contents

    Cross-talk among microbial cells. Interaction of commensal, probiotic or pathogen microorganisms with animal cells and tissues. Microbial biotechnologies: metabolic engineering of microbial strains for biotechnological productions.

    Textbook and course materials

    Human Microbiota and Microbiome - Advances in Molecular and Cellular Microbiology
    Ed. J Marchesi, Cardiff University, UK, 2014.
    Cellular Microbiology, P. Cossart, P. Bouquet, S. Normark, R. Rappuoli. ASM Press, 2005.
    Scientific research articles and reviews provided by the lecturer

    Course objectives

    The objective of this course is to provide an overview of cellular microbiology applied to human health. Moreover, the course will give an overview of biotechnological strategies in microorganisms for production of molecules related to human health.

    Prerequisites

    Knowledge acquired with a Bachelor degree in Biotechnology or in Biology, or equivalent academic degrees.

    Teaching methods

    Frontal lessons and seminars

    Evaluation methods

    Verification of learning consist in an oral exam. Questions are organized in three parts, corresponding to the three sections of the course program.

    Other information

    Supplementary material will be provided during the course. The lecturer will receive students during the office hours indicated or on request submitted via e-mail

    Course Syllabus

    FIRST PART
    Cross-talk among microbial cells: quorum sensing, quorum quenching. Examples of human quorum quenching versus pathogens. The role of bacterial biofilms in chronic infectious diseases.

    SECOND PART
    Host-microbe interaction. The human gut microbiota in health and disease. Commensal and probiotic microorganisms in competitive exclusion mechanisms. Next generation sequencing methods to investigate the human microbiome. Microbial pathogenesis: adhesion and invasion (trigger and zipper mechanisms), type III and IV secretion systems, pathogenicity island, toxins.
    Development of multidrug resistance: efflux pumps in pathogenic mycobacteria.

    THIRD PART
    Characteristics of microbial strains used for production of metabolites or heterologous proteins. Metabolic engineering of microbial strains for production of vitamins and amino acids. Innovative strategies for search and production of new antimicrobial molecules.

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