INGLESE

The course will focus on the Molecular mechanisms responsible for pathological phenomena and the role of the Immune response in human diseases. Oncology, Immunology and Immunopathology will be discussed.

The latest edition of:
Peter Parham “The immune system”
Abul Abbas “Cellular and Molecular Immunology”
Kennet Murphy “Janeway’s Immunobiology”

COURSE OBJECTIVES/OUTCOMES:
To understand the molecular basis and the mechanisms leading to the onset of pathological phenomena in humans. To understand the role of the immune system in preventing disease.

B1 Knowledge of english

Frontal lessons

Oral examen to verify the accomplishment of the course objectives, especially for the understanding of the molecular mechanisms leading to pathological conditions.

ADDITIONAL READING:
The cancer Immunotherapy mechanistic insights (J immunol monography 2018)
Costa V et al “uncovering the complexity of transcriptomes with RNA seq (J immunol and Biotecnol. 2010)
Metzker M “Sequencing technologies the next generation” (Nat Rev Gen 2009)
Cossarizza A et al “Guidelines for the use of flow cytometry and cell sorting in immunological studies” (eur J Immunol 2017)

SYLLABUS (Detailed description):
Cells and Tissues of the Immune System
Innate Immunity and Inflammation:
Natural Killer Cells
TLR signaling
Cytokines and chemokines
Adaptative Immunity:
Antibody Structure and Antigens
MHC Structure and Antigen Presentation
Antigen Receptors and Accessory Molecules
Lymphocyte Development and Expression of Antigen Receptors (BCR/TCR)
B cell receptor . Structure and function of Immunoglobulins. Molecular Genetics. Antigen-antibody interactions.
Regulation of the Immune Response
Lymphocyte Activation and Signal Transduction
Signal transduction to T lymphocytes. ITAM and phosphorylation.

Immunopathology:
Autoimmunity and Hypersensitivities
Immune Deficiencies
Immunological Tolerance

Vaccines:
Prophylactic and therapeutic vaccines. Role of humoral and cellular immune response. Correlates of protection. Impact and society concern. Side effects. Role of adjuvants. New generation vaccines.
OMIC analyses. Next generation sequencing. Applications in the study of the immune response.
T cell receptor. Molecular Genetics. The CD3 complex. Mechanisms of T cell recognition.
Cytofluorimetry (principles and applications in the study of the immune response)
Cancer Immunotherapy. Tumor associated antigens, tumor escape. Immuno-therapeutic markers and validated assays for monitoring the tumor-specific immune response. Adoptive T cell Therapy (CAR T and TCR).

English

The course will focus on the Molecular mechanisms responsible for pathological phenomena and the role of the Immune response in human diseases. Oncology, Immunology and Immunopathology will be discussed.

The latest edition of:
Peter Parham “The immune system”
Abul Abbas “Cellular and Molecular Immunology”
Kennet Murphy “Janeway’s Immunobiology”

COURSE OBJECTIVES/OUTCOMES:
To understand the molecular basis and the mechanisms leading to the onset of pathological phenomena in humans. To understand the role of the immune system in preventing disease.

B1 Knowledge of english

Frontal lessons

Oral examen to verify the accomplishment of the course objectives, especially for the understanding of the molecular mechanisms leading to pathological conditions.

ADDITIONAL READING:
The cancer Immunotherapy mechanistic insights (J immunol monography 2018)
Costa V et al “uncovering the complexity of transcriptomes with RNA seq (J immunol and Biotecnol. 2010)
Metzker M “Sequencing technologies the next generation” (Nat Rev Gen 2009)
Cossarizza A et al “Guidelines for the use of flow cytometry and cell sorting in immunological studies” (eur J Immunol 2017)

SYLLABUS (Detailed description):
Cells and Tissues of the Immune System
Innate Immunity and Inflammation:
Natural Killer Cells
TLR signaling
Cytokines and chemokines
Adaptative Immunity:
Antibody Structure and Antigens
MHC Structure and Antigen Presentation
Antigen Receptors and Accessory Molecules
Lymphocyte Development and Expression of Antigen Receptors (BCR/TCR)
B cell receptor . Structure and function of Immunoglobulins. Molecular Genetics. Antigen-antibody interactions.
Regulation of the Immune Response
Lymphocyte Activation and Signal Transduction
Signal transduction to T lymphocytes. ITAM and phosphorylation.

Immunopathology:
Autoimmunity and Hypersensitivities
Immune Deficiencies
Immunological Tolerance

Vaccines:
Prophylactic and therapeutic vaccines. Role of humoral and cellular immune response. Correlates of protection. Impact and society concern. Side effects. Role of adjuvants. New generation vaccines.
OMIC analyses. Next generation sequencing. Applications in the study of the immune response.
T cell receptor. Molecular Genetics. The CD3 complex. Mechanisms of T cell recognition.
Cytofluorimetry (principles and applications in the study of the immune response)
Cancer Immunotherapy. Tumor associated antigens, tumor escape. Immuno-therapeutic markers and validated assays for monitoring the tumor-specific immune response. Adoptive T cell Therapy (CAR T and TCR).