INGLESE

English

Molecular recognition in biomolecules
Biomolecules as Drug;
The word of Peptide and its analogues for Drug Design;
Secondary structure in protein and in peptide
Molecular Recognition: the structural and chemical physics basis;
Drugs the function in biological systems;
The Drug Design;
Molecular Tools for design of peptides: Examples: Helix Design, Protein Structure, Prediction and its application to thermostable proteins, Design of selective bioactive

Bibliography provided by the teacher

The aim of this course is to introduce the theory and practice for the design of bioactive compounds using different theoretical and experimental techniques of Structural Chemistry and Biology (X-ray diffraction, NMR spectroscopy, Computational techniques). At the end of the course,the student knows the chemical basis of the structure and structural and functional properties of natural and synthetic peptide systems and is able to understand the logic that governs their design to perform specific biological functions. It is able to find information on the structure of peptide systems and complexes with proteins and nucleic acids in databases and to analyze their spatial structure. Understands the importance, through specific examples, of knowledge of peptide chemistry in application fields such as diagnostics and pharmaceuticals

No propaedeutic. Basic knowledge of Inorganic and Organic Chemistry, Mathematics, Physics, Biochemistry and Biology

The attendance to the lessons is mandatory. The course is organized in 48 hours of frontal lessons that will be theoretical and practical.

The final examination will consist in an oral interview, aimed to verify the notion acquired and the ability of the student to re-elaborates the contents presented during the course. In particular, the oral examinations are aimed to evaluate the capability of reasoning and connecting the various arguments of the course and is constituted by questions about the theoretical part of the course to evaluate the knowledge of the studied subjects and the capability to organize the exposition and connection of the diverse arguments.

During the course slides and notes of the lectures will be provided to the students via Teams.
Each Professor is available for student reception during the office hour as reported in the course sheet or by e-mail request

Programma esteso PROGR_EST Sì - The Peptides. Nomenclature. Non-natural amino acids. Permitted conformations. Ramachandran maps of natural and non-natural amino acids. Characteristics of the peptide bond. Acidity and basicity in peptides, calculation of the isoelectric point.
-Characterization of peptides. Secondary structure. Turn.. Prediction of the three-dimensional structure using computational techniques. Solid state studies using diffraction and IR techniques. Characterization in solution with circular dichroism, NMR, IR and fluorescence techniques
- Peptides as drugs and diagnostics: Principles of Drug Design, The design of peptide drugs. Examples of applications in diagnosis and therapy
- Databases for peptide structures and complexes with proteins and DNA: Protein Data Bank and CCSD.
- Molecular Tools for design of peptides: Examples: Helix Design, Protein Structure, Prediction and its application to thermostable proteins, Design of selective bioactive molecules for therapeutic applications.